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β-catenin activation disrupts the normal cellular balance between growth, death, and differentiation, tipping the scales towards uncontrolled growth and tumor formation. It also creates an environment that favors tumor persistence and metastasis. For example, when activated, β-catenin travels to the nucleus and binds to DNA, promoting the expression of genes involved in cell growth and division....
Beta-Catenin Activation Reprograms Ammonia Metabolism
May 22, 2024
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Recent research shows cellular plasticity drives cancer metastasis. Cancer cells can adapt and change their characteristics, enabling them to spread to other parts of the body. This acquired property allows these cells to adapt to the pressures and metabolic demands of very different environments. For example, metastatic cancer cells seem to be able to survive in new environments by reprogramming ...
Iron utilization and the Wnt/beta-catenin pathway
May 21, 2024
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