Extracellular vesicles (EVs) are secreted, nanometer-scale genetic information carriers found in human biofluids. To analyze these data, many tools have been launched to identify molecular groups. Next-generation sequencing (NGS) has been introduced to analyze exosomal RNA. Creative Biolabs has optimized our technology platform with advanced equipment and experienced experts to help our customers accelerate their researches with high-efficient and high-quality RNA sequencing services.
Overview of Exosomal Nucleic Acids
The first report that exosomes contain nucleic acids was in 2007. That research showed that exosomes contain RNAs (mRNA/microRNA) that can be transferred to and remain functional in receptor cells. More importantly, exosomal mRNA can be translated to proteins in receptor cells, and some exosomal miRNA can bind and regulate mRNAs of recipient cells. Furthermore, exosomes also contain DNA fragments, but their function has yet to be understood. Several studies have shown that the transferred RNA can regulate the processes of receptor cells, such as apoptosis and differentiation. These discoveries spark research interest in the field of exosomes as specific cellular messengers for nucleic acid-based cell-to-cell communication.
Learn more: exosome sequencing